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To establish the PBPK model, the tissue-to-plasma partition coefficient (Kp) values were simultaneously optimized based on the system-built-in Lukacova (Rodgers-Single) method

Neutrophils were incubated with Heptelidic acid (HA) or iodoacetate (IA) at the doses and timepoints indicated in the results

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Methods: Peripheral blood from 23 transfusion-dependent MDS patients was analysed in a paired pre-/post-treatment design

However, SL application increased drought tolerance in Brassica rapa by improving the antioxidant defense system that reduced ROS and MDA content ( Medicago truncatula roots, leading to a high expression of SL biosynthetic genes ( 9.2 Salicylic acid Salicylic acid (SA) is a powerful phytohormone that contributes to the production of ROS in excess (acting as a pro-oxidant) while also boosting the activity of ROS-scavenging enzymes (antioxidants) during stressful conditions ( 2 O 2 , which serves as a key signal to activate the antioxidant defense system, helping the plants to cope with abiotic stress